Prognostic factor

P-value

Hazard ratio

95% Confidence interval

Differentiation (High grade^a)

0.03

2.50

1.11 - 5.63

Invasion depth (T4)

0.09

1.74

0.90 - 3.35

Lymphatic invasion (Moderate-severe)

0.02

3.23

1.23 - 8.50

Venous invasion (Moderate-severe)

0.15

1.61

0.85 - 3.04

TNM classification,7^th edition (IIIC)

0.04

1.94

1.01 - 3.70